Characterization of a nuclear localization signal in the foot-and-mouth disease virus polymerase.


We have experimentally tested whether the MRKTKLAPT sequence in FMDV 3D protein (residues 16 to 24) can act as a nuclear localization signal (NLS). Mutants with substitutions in two basic residues within this sequence, K18E and K20E, were generated. A decreased nuclear localization was observed in transiently expressed 3D and its precursor 3CD, suggesting a… (More)
DOI: 10.1016/j.virol.2013.06.011


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