Characterization of a novel sphingosine 1-phosphate receptor, Edg-8.

  title={Characterization of a novel sphingosine 1-phosphate receptor, Edg-8.},
  author={Dong-Soon Im and Christopher E. Heise and Nicolas Ancellin and Brian F O'dowd and G J Shei and Robert P. Heavens and M R Rigby and Timothy Hla and Suzanne Mandala and G Mcallister and Susan R. George and Kevin R Lynch},
  journal={The Journal of biological chemistry},
  volume={275 19},
Three G protein-coupled receptors (Edg-1, Edg-3, and Edg-5) for the lysolipid phosphoric acid mediator sphingosine 1-phosphate have been described by molecular cloning. Using a similar sequence that we found in the expressed sequence tag data base, we cloned and characterized of a fourth, high affinity, rat brain sphingosine 1-phosphate receptor, Edg-8. When HEK293T cells were co-transfected with Edg-8 and G protein DNAs, prepared membranes showed sphingosine 1- phosphate-dependent increases in… CONTINUE READING
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