Characterization of a novel putative cognition enhancer mediating facilitation of glycine effect on strychnine-resistant sites coupled to NMDA receptor complex

@article{Lanza1997CharacterizationOA,
  title={Characterization of a novel putative cognition enhancer mediating facilitation of glycine effect on strychnine-resistant sites coupled to NMDA receptor complex},
  author={Marco Lanza and Cécile Bonnafous and Sergio L Colombo and Laura Revel and Francesco Makovec},
  journal={Neuropharmacology},
  year={1997},
  volume={36},
  pages={1057-1064}
}
The "kynurenate test", a biochemical assay for putative cognition enhancers.
TLDR
The "kynurenate test" is an in vitro assay useful in the identification and characterization of putative cognition enhancers acting via NMDA receptors and may bind to sites different from the glycine site of the NMDA receptor.
Activity of putative cognition enhancers in kynurenate test performed with human neocortex slices.
TLDR
The similarities between the data obtained here with human neocortex slices and those previously obtained in the rat indicate that the kynurenate test performed with rat brain slices may represent a useful biochemical assay to study cognition-enhancing drugs.
Cognition Enhancing Profile of CR 2249, a New NMDA‐Glycine Site Modulator
TLDR
Two different neurotransmission models are of major interest in understanding how the brain can acquire and store a single cognitive event: long-term potentiation and glutamatergic.
Novel NMDA receptor modulators: an update
TLDR
First-in-class potentiators and subunit-selective agents form the basis for most new strategies, complemented by efforts to limit off-target liability and fine-tune on-target properties.

References

SHOWING 1-10 OF 49 REFERENCES
3H-labeled MK-801 binding to the excitatory amino acid receptor complex from rat brain is enhanced by glycine.
TLDR
Glycine regulated 3H-labeled MK-801 binding, and enhanced the ability of N-methyl-D-aspartate to increase Ca2+ influx into primary cultures of mouse striatal neurons measured using the Ca2-sensitive fluorescent dye fura-2.
Phencyclidine selectively inhibits N-methyl-D-aspartate-induced hippocampal [3H]norepinephrine release.
TLDR
The data suggest that PCP is a potent, selective, noncompetitive inhibitor of amino acid-induced [3H]NE release and that this action is mediated through the PCP/sigma receptor.
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