Characterization of a novel protein-binding module--the WW domain.

  title={Characterization of a novel protein-binding module--the WW domain.},
  author={Marius Sudol and Hai-Feng Chen and C Bougeret and Aaron Einbond and Peer Bork},
  journal={FEBS letters},
  volume={369 1},
We have identified, characterized and cloned human, mouse and chicken cDNA of a novel protein that binds to the Src homology domain 3 (SH3) of the Yes proto-oncogene product. We subsequently named it YAP for Yes-associated protein. Analysis of the YAP sequence revealed a protein module that was found in various structural, regulatory and signaling molecules. Because one of the prominent features of this sequence motif is the presence of two conserved tryptophans (W), we named it the WW domain… CONTINUE READING


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