Characterization of a novel promoter insertion in the c-rel locus.

@article{Kabrun1990CharacterizationOA,
  title={Characterization of a novel promoter insertion in the c-rel locus.},
  author={N Kabrun and Nat Bumstead and Michael J Hayman and Paula J Enrietto},
  journal={Molecular and cellular biology},
  year={1990},
  volume={10 9},
  pages={4788-94}
}
Avian leukosis virus (ALV)-induced neoplasias are commonly found associated with integrations of proviral DNA in proximity to the myc gene. However, studies suggest that other genetic events are necessary for the complete neoplastic phenotype. A cell line (HP46) derived from an ALV-induced tumor has been analyzed and found to contain, in addition to an alteration in the myc gene, a promoter insertion in the c-rel locus. Both loci expressed large amounts of mRNA coding for their respective… CONTINUE READING