Characterization of a novel posttranslational modification in polypyrimidine tract-binding proteins by SUMO1

@inproceedings{Han2014CharacterizationOA,
  title={Characterization of a novel posttranslational modification in polypyrimidine tract-binding proteins by SUMO1},
  author={Wei Han and Lin Wang and Benshun Yin and Xiaozhong Peng},
  booktitle={BMB reports},
  year={2014}
}
Polypyrimidine tract-binding protein 1 (PTBP1) and its brainspecific homologue, PTBP2, are associated with pre-mRNAs and influence pre-mRNA processing, as well as mRNA metabolism and transport. They play important roles in neural differentiation and glioma development. In our study, we detected the expression of the two proteins in glioma cells and predicted that they may be sumoylated using SUMOplot analyses. We confirmed that PTBP1 and PTBP2 can be modified by SUMO1 with co… CONTINUE READING

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