Characterization of a novel monoclonal antibody reactive against the N-terminal region of Enterovirus 71 VP1 capsid protein.

@article{Lim2013CharacterizationOA,
  title={Characterization of a novel monoclonal antibody reactive against the N-terminal region of Enterovirus 71 VP1 capsid protein.},
  author={Xiao Fang Lim and Qiang Jia and Vincent T. K. Chow and Jimmy Kwang},
  journal={Journal of virological methods},
  year={2013},
  volume={188 1-2},
  pages={76-82}
}
Hand, foot and mouth disease (HFMD) is a viral infectious disease caused by human Enterovirus A, particularly Enterovirus 71 (EV71) and Coxsackievirus 16 (CA16) serotypes, with EV71 infection associated with severe neurological complications and mortality. Lots of attention has been placed on elucidating viral epitopes, which is useful for EV71 viral research. In this study, a murine monoclonal antibody (mAb 4) specific for EV71 was generated and mapped to target the N-terminal region of VP1… CONTINUE READING