Characterization of a novel microdeletion polymorphism on BTA5 in cattle.

@article{Liu2008CharacterizationOA,
  title={Characterization of a novel microdeletion polymorphism on BTA5 in cattle.},
  author={George E. Liu and Robert W. Li and Tad S. Sonstegard and Lakshmi K. Matukumalli and Marcos Vinicius Gualberto Barbosa da Silva and Curtis P Van Tassell},
  journal={Animal genetics},
  year={2008},
  volume={39 6},
  pages={
          655-8
        }
}
We present a detailed breakpoint mapping and population frequency analysis of a 214-kb microdeletion that removes multiple olfactory receptor genes. Using progressive rounds of PCR assays, we mapped the upstream and downstream breakpoints of this microdeletion event to approximately 1 and 12 kb genomic regions, respectively. We developed PCR-based genotyping assays, characterized a dairy cattle panel of 96 samples and found that the frequency of the deletion allele was over 51%. Our results… CONTINUE READING

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