Characterization of a novel lymph node metastasis model from human colonic cancer and its preclinical use for comparison of anti-metastatic efficacy between oral S-1 and UFT/ LV.

@article{Ito2010CharacterizationOA,
  title={Characterization of a novel lymph node metastasis model from human colonic cancer and its preclinical use for comparison of anti-metastatic efficacy between oral S-1 and UFT/ LV.},
  author={Yuichi Ito and Hayao Nakanishi and Yasuhiro Kodera and Takashi Hirai and Akimasa Nakao and Tomoyuki Kato},
  journal={Cancer science},
  year={2010},
  volume={101 8},
  pages={1853-60}
}
Although lymph node metastasis (LNM) is the most critical prognostic factor in colorectal cancer patients, the anti-LNM efficacy of chemotherapeutic agents is largely unknown because of the limitations of reproducible human colorectal cancer LNM models. Here, we developed a new LNM model from a recently established colorectal cancer cell line (COLM-5) and compared the anti-LNM efficacy of two oral formulations of 5-fluorouracil (5-FU) derivatives, S-1 and UFT/leucovorin (LV). COLM-5 cells is a… CONTINUE READING