Characterization of a novel low-molecular-mass dual-specificity phosphatase-3 (LDP-3) that enhances activation of JNK and p38.

@article{Takagaki2004CharacterizationOA,
  title={Characterization of a novel low-molecular-mass dual-specificity phosphatase-3 (LDP-3) that enhances activation of JNK and p38.},
  author={Kentaro Takagaki and Takeshi Satoh and Nobuhiro Tanuma and Kouhei Masuda and Mutsuhiro Takekawa and Hiroshi Shima and Kunimi Kikuchi},
  journal={The Biochemical journal},
  year={2004},
  volume={383 Pt. 3},
  pages={447-55}
}
We have isolated a mouse cDNA for a novel dual-specificity phosphatase designated LDP-3 (low-molecular-mass dual-specificity phosphatase 3). The 450 bp open reading frame encodes a protein of 150 amino acids with a predicted molecular mass of 16 kDa. Northern blot and reverse transcription-PCR analyses show that LDP-3 transcripts are expressed in almost all mouse tissues examined. In vitro analyses using several substrates and inhibitors indicate that LDP-3 possesses intrinsic dual-specificity… CONTINUE READING

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