Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor.

@article{Porter2002CharacterizationOA,
  title={Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor.},
  author={A. Porter and J. Sauer and M. Knierman and G. Becker and M. Bern{\'a} and J. Bao and G. Nomikos and P. Carter and F. Bymaster and Andrea Baker Leese and C. Felder},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={301 3},
  pages={
          1020-4
        }
}
  • A. Porter, J. Sauer, +8 authors C. Felder
  • Published 2002
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
The first endocannabinoid, anandamide, was discovered in 1992. Since then, two other endocannabinoid agonists have been identified, 2-arachidonyl glycerol and, more recently, noladin ether. Here, we report the identification and pharmacological characterization of a novel endocannabinoid, virodhamine, with antagonist properties at the CB1 cannabinoid receptor. Virodhamine is arachidonic acid and ethanolamine joined by an ester linkage. Concentrations of virodhamine measured by liquid… Expand
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References

SHOWING 1-10 OF 15 REFERENCES
Carrier-mediated uptake of the endogenous cannabinoid anandamide in RBL-2H3 cells.
  • 141
Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction.
  • 438
  • PDF
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.
  • 2,507
The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice.
  • 390
2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor
  • 743
  • PDF
Isolation and structure of a brain constituent that binds to the cannabinoid receptor.
  • 4,816
Role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid anandamide.
  • 129
  • PDF
Pharmacology of cannabinoid receptor ligands.
  • R. Pertwee
  • Chemistry, Medicine
  • Current medicinal chemistry
  • 1999
  • 497
...
1
2
...