Characterization of a novel aldose reductase inhibitor, TAT, and its effects on streptozotocin-induced diabetic neuropathy in rats.

@article{Inukai1993CharacterizationOA,
  title={Characterization of a novel aldose reductase inhibitor, TAT, and its effects on streptozotocin-induced diabetic neuropathy in rats.},
  author={Shinji Inukai and Masato Agata and Masayuki Sato and Asuka Naitou and Hiroaki Matsukawa and Makoto Goto},
  journal={Japanese journal of pharmacology},
  year={1993},
  volume={61 3},
  pages={221-7}
}
TAT ([5-(3-thienyl)tetrazol-1-yl]acetic acid) is a novel aldose reductase (AR) inhibitor. It exhibited highly potent inhibition of partially purified AR from rat lens (IC50 = 2.1 x 10(-8) M), rabbit lens (IC50 = 2.3 x 10(-8) M) and human placenta (IC50 = 2.8 x 10(-8) M). On the other hand, TAT had a weak inhibitory activity against mouse liver aldehyde… CONTINUE READING