Characterization of a novel adenosine binding protein sensitive to cyclic AMP in rat brain cytosolic and particulate fractions.

@article{Lorenzen1996CharacterizationOA,
  title={Characterization of a novel adenosine binding protein sensitive to cyclic AMP in rat brain cytosolic and particulate fractions.},
  author={A. Lorenzen and B. Grossekatth{\"o}fer and B. Kerst and H. Vogt and T. Fein and U. Schwabe},
  journal={Biochemical pharmacology},
  year={1996},
  volume={52 9},
  pages={
          1375-85
        }
}
A novel binding site for the adenosine receptor agonist 5'-N-ethylcarboxamidoadenosine (NECA), which was enriched in rat forebrain, was characterized in cytosolic and particulate preparations. The site showed a pharmacological profile different from other [3H]NECA binding proteins and was named adenotin 2. [3H]NECA was bound in the presence of 100 microM 2-chloroadenosine with a Kd of 45.4 nM and a Bmax of 4711 fmol/mg in the cytosol and a Kd of 72.4 nM and a Bmax of 4844 fmol/mg in the crude… Expand
Pharmacology Of A Unique Adenosine Binding Site In Rat Brain Using A Selective Ligand
The Concise Guide to Pharmacology 2013/14: G Protein-Coupled Receptors

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