Characterization of a novel O(1) variant allele at the ABO blood group locus.

@article{Bugert2001CharacterizationOA,
  title={Characterization of a novel O(1) variant allele at the ABO blood group locus.},
  author={Peter Bugert and L R{\"u}tten and Siegfried Goerg and Harald Kl{\"u}ter},
  journal={Tissue antigens},
  year={2001},
  volume={58 6},
  pages={422-4}
}
We describe the identification and molecular characterization of a novel variant O(1) allele of the ABO blood group locus. The allele was found in a young child and by analyzing the maternal DNA we were able to show that a meiotic recombination event between the maternal O(1v-3) and B(1-1) alleles recreated a O(1)/B hybrid allele. Further characterization of intron 6 sequences delineated the putative recombination breakpoint between nucleotide position 42 and 163 of the intron. We propose that… CONTINUE READING