Characterization of a new platelet aggregating factor from crotoxin Crotalus durissus cascavella venom.

@article{Fonseca2006CharacterizationOA,
  title={Characterization of a new platelet aggregating factor from crotoxin Crotalus durissus cascavella venom.},
  author={F V Fonseca and Edson Antunes and Rafael Prada Morganti and H. Monteiro and Ana M Martins and Daniela de Oliveira Toyama and S{\'e}rgio Marangoni and Marcos Hikari Toyama},
  journal={The protein journal},
  year={2006},
  volume={25 3},
  pages={183-92}
}
In this article we investigated the platelet aggregating activity of whole crotoxin and its subunits isolated from Crotalus durissus cascavella venom. During the purification protocols of the venom, using HPLC molecular exclusion, we detected the presence of two different serine protease activities in the gyroxin fraction, and another in the crotoxin fraction, which induced strong and irreversible platelet aggregation, in addition to blood coagulation. From crotoxin, we isolated PLA2… CONTINUE READING