Characterization of a new muscarinic receptor antagonist PNU-171990 in guinea pig, cat and human smooth muscle.

  title={Characterization of a new muscarinic receptor antagonist PNU-171990 in guinea pig, cat and human smooth muscle.},
  author={A R Modiri and Mervi Vas{\"a}nge and Pēteris Alberts and Sukhwinder Singh Jossan and Staffan Sundquist and Per G{\"o}ran Gillberg},
  journal={European journal of pharmacology},
  volume={451 2},
Research Frontiers in the Treatment of Urinary Incontinence
This chapter aims to describe a brief framework upon which the future of therapy for urinary incontinence can be constructed and to highlight relevant topics that emphasize translational studies that apply directly to the clinical treatment of urinaryincontinence.


Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo
In urethane‐anaesthetized rats, the cholinergic component of volume‐induced bladder contractions was inhibited by muscarinic antagonists but had marginal effects on pinacidil‐induced, adenosine 3′:5′‐cyclic monophosphate (cyclic AMP)‐independent, relaxation, consistent with a major contribution of M2 receptors in the generation of volume-induced bladdercontractions.
The mechanism of action of topiramate
A combination of pharmacological properties that may explain why topiramate is effective in both partial and generalized seizures, and why it is proving efficacious in numerous intractable syndromic epilepsies.
The effects of atropine on [3H]acetylcholine secretion from guinea‐pig myenteric plexus evoked electrically or by high potassium
1. The myenteric plexus‐longitudinal muscle preparation of the guinea‐pig ileum was incubated with [3H]choline (1·125‐1·5 μM), and then superfused with Tyrode solution containing hemicholinium‐3 (10
Presynaptic antagonist-postsynaptic agonist at muscarinic cholinergic synapses. N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.
A muscarinic cholinergic ligand, N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)-acetamide (Compound BM-5), was shown to act simultaneously as a presynaptic antagonist and as a postsynaptic agonist at
Clinical experiences with tolterodine.
International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors.
Actions of acetylcholine in the periphery are the result of activation of either the ionotropic nicotinic receptor or the metabotropic muscarinic receptor. In the mammalian central nervous system