Characterization of a new animal model for evaluation and treatment of back pain due to lumbar facet joint osteoarthritis.

@article{Kim2011CharacterizationOA,
  title={Characterization of a new animal model for evaluation and treatment of back pain due to lumbar facet joint osteoarthritis.},
  author={Jae-Sung Kim and JeffreyS. Kroin and Asokumar Buvanendran and Xin Li and Andre J van Wijnen and Kenneth J. Tuman and Hyun Sik Im},
  journal={Arthritis and rheumatism},
  year={2011},
  volume={63 10},
  pages={
          2966-73
        }
}
OBJECTIVE Osteoarthritic (OA) degeneration of the lumbar facet joints has been implicated in low back pain. This study was undertaken to investigate the biologic links between cellular and structural alterations within facet joint components and the development of symptomatic chronic back pain. METHODS We generated an animal model of facet joint degeneration by intraarticular injection of monosodium iodoacetate (MIA) into facet joints (L3-L4, L4-L5, L5-L6) of Sprague-Dawley rats. Pain… CONTINUE READING
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