Characterization of a neuronal cell line expressing native human melanin-concentrating hormone receptor 1 (MCHR1).

@article{Fry2006CharacterizationOA,
  title={Characterization of a neuronal cell line expressing native human melanin-concentrating hormone receptor 1 (MCHR1).},
  author={Dennis G Fry and Brian D Dayton and Sevan J Brodjian and Christopher A Ogiela and Hanna Sidorowicz and Leigh J Frost and Teresa McNally and Regina M. Reilly and Christine A Collins},
  journal={The international journal of biochemistry & cell biology},
  year={2006},
  volume={38 8},
  pages={1290-9}
}
Melanin-concentrating hormone (MCH), an orexigenic neuropeptide in mammals, activates a G-protein coupled receptor, MCHR1. It is expected that antagonists of MCHR1 function will prove therapeutically useful as anti-obesity agents. Intracellular signaling by MCHR1 has been investigated primarily using non-neural cell lines expressing the recombinant receptor, in which MCHR1 has been shown to couple to G alpha(i/o) and G alpha(q) G-proteins. While these cell lines have been widely utilized to… CONTINUE READING

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