Characterization of a myxoma virus-encoded serpin-like protein with activity against interleukin-1 beta-converting enzyme.

@article{Petit1996CharacterizationOA,
  title={Characterization of a myxoma virus-encoded serpin-like protein with activity against interleukin-1 beta-converting enzyme.},
  author={Françoise Petit and St{\'e}phane Bertagnoli and Jacqueline Gelfi and Florence Fassy and Corine Boucraut-Baralon and Alain Milon},
  journal={Journal of virology},
  year={1996},
  volume={70 9},
  pages={5860-6}
}
A genomic library of myxoma virus (MV) DNA, a leporipoxvirus that causes myxomatosis, was constructed and screened by in vitro transcription-translation. A clone was selected on the basis of its strong reactivity with MV antiserum. Analysis of the corresponding DNA sequence and the deduced amino acid sequence revealed an open reading frame coding for a 34-kDa protein with strong homologies to members of the serpin superfamily. The gene encoding this new protein, called serp2, was localized on… CONTINUE READING

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