Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages.

@article{Lohse2012CharacterizationOA,
  title={Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages.},
  author={Stefan Lohse and Christina Brunke and Stefanie Derer and Matthias Peipp and Peter Boross and Christian Johannes Kellner and Thomas D. Beyer and Michael Dechant and Jan G J van der Winkel and Jeanette H W Leusen and Thomas Valerius},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 30},
  pages={25139-50}
}
IgA antibodies constitute an important part of the mucosal immune system, but their immunotherapeutic potential remains rather unexplored, in part due to biotechnological issues. For example, the IgA2m(1) allotype carries an unusual heavy and light chain pairing, which may confer production and stability concerns. Here, we report the generation and the biochemical and functional characterization of a P221R-mutated IgA2m(1) antibody against the epidermal growth factor receptor (EGFR). Compared… CONTINUE READING
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