Characterization of a mutant of Toxoplasma gondii resistant to aphidicolin.

@article{Pfefferkorn1984CharacterizationOA,
  title={Characterization of a mutant of Toxoplasma gondii resistant to aphidicolin.},
  author={Elmer R. Pfefferkorn},
  journal={The Journal of protozoology},
  year={1984},
  volume={31 2},
  pages={306-10}
}
Aphidicolin, a mycotoxin that inhibits eucaryotic DNA polymerase alpha, blocked the growth of Toxoplasma gondii in confluent cultured human fibroblasts. Aphidicolin immediately inhibited DNA synthesis by T. gondii while it had a delayed and less dramatic effect on RNA synthesis. A mutant of T. gondii resistant to aphidicolin was isolated with the aid of… CONTINUE READING