Characterization of a mutant E-cadherin protein encoded by a mutant gene frequently seen in diffuse-type human gastric carcinoma.

@article{Fukudome2000CharacterizationOA,
  title={Characterization of a mutant E-cadherin protein encoded by a mutant gene frequently seen in diffuse-type human gastric carcinoma.},
  author={Y Fukudome and Kazuyoshi Yanagihara and Masatoshi Takeichi and Fumiaki Ito and Sayumi Shibamoto},
  journal={International journal of cancer},
  year={2000},
  volume={88 4},
  pages={
          579-83
        }
}
The cell-cell adhesion molecule E-cadherin plays an essential role in the maintenance and function of epithelial tissues. Altered expression of E-cadherin has been implicated in tumor invasion. Analysis of mutations of the human E-cadherin gene in gastric carcinoma of the diffuse type has revealed that deletion of exon 8 or 9 in its cDNA appears to be predominant. In this study, we carried out structural and functional analyses of a mutant form of E-cadherin in a cell line, HSC45-M2… CONTINUE READING

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