Characterization of a murine gene homologous to the bovine CaCC chloride channel.

@article{Romio1999CharacterizationOA,
  title={Characterization of a murine gene homologous to the bovine CaCC chloride channel.},
  author={Leila Romio and Luciana Musante and Roberta Cinti and Marco Seri and Oscar Mor{\'a}n and Olga Zegarra-Moran and Luis J. V. Galietta},
  journal={Gene},
  year={1999},
  volume={228 1-2},
  pages={181-8}
}
The bovine CaCC protein is a putative Ca2+-dependent Cl- channel of airway epithelial cells. Therefore, CaCC proteins could contribute to transepithelial Cl- transport and accordingly modify the phenotype of cystic fibrosis (CF) patients. We have identified a murine EST containing a full-length cDNA coding for a 902-amino-acid protein highly homologous to bovine CaCC. The murine gene (mCaCC) maps to chromosome 3 at the H2-H3 band and is expressed, as indicated by Northern blot analysis, in… CONTINUE READING