Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes.

@article{Iizuka2005CharacterizationOA,
  title={Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes.},
  author={Yoshiko Iizuka and Takehiko Yokomizo and Kan Terawaki and Mayumi Komine and K. Shimoji T. Kurokawa T. Tamaki and Takao Shimizu},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 26},
  pages={24816-23}
}
Leukotriene B4 (LTB4) is a potent chemoattractant and activator for granulocytes and macrophages and is considered to be an inflammatory mediator. Two G-protein-coupled receptors for LTB4, BLT1 and BLT2, have been cloned from human and shown to be high and low affinity LTB4 receptors, respectively. To reveal the biological roles of BLT2 using mouse disease models, we cloned and characterized mouse BLT2. Chinese hamster ovary cells stably expressing mouse BLT2 exhibited specific binding to LTB4… CONTINUE READING

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