Characterization of a lymphokine produced by human T cells which inhibits collagen synthesis.

@article{Rosenbloom1983CharacterizationOA,
  title={Characterization of a lymphokine produced by human T cells which inhibits collagen synthesis.},
  author={Joel Rosenbloom and W M McArthur and Daniel I. Malamud and Sergio A Jimenez},
  journal={Cellular immunology},
  year={1983},
  volume={81 1},
  pages={192-8}
}
Human lymphocytes, isolated from peripheral blood, were cultured for 48 hr in a defined medium containing 10 mg/ml bovine serum albumin and phytohemagglutinin. A lymphokine which inhibits collagen synthesis by cultured human dermal fibroblasts was purified from the lymphocyte incubation medium by successive steps of ammonium sulfate precipitation, gel… CONTINUE READING