Characterization of a low affinity thyroid hormone receptor binding site within the rat GLUT4 gene promoter.

@article{Torrance1997CharacterizationOA,
  title={Characterization of a low affinity thyroid hormone receptor binding site within the rat GLUT4 gene promoter.},
  author={C J Torrance and S J Usala and Jeffrey E. Pessin and Gerald L Dohm},
  journal={Endocrinology},
  year={1997},
  volume={138 3},
  pages={1215-23}
}
Previous studies have demonstrated that thyroid hormone (T3) stimulates insulin-responsive glucose transporter (GLUT4) transcription and protein expression in rat skeletal muscle. The aim of the present study was to define a putative thyroid hormone response element (TRE) within the rat GLUT4 promoter and thus perhaps determine whether T3 acts directly to augment skeletal muscle GLUT4 transcription. To this end, electrophoretic mobility shift analyses were performed to analyze thyroid hormone… CONTINUE READING