Characterization of a liver metastatic variant of murine K1735M2 melanoma cells.


Intraportal vein injection of highly metastatic K1735M2L5 cells consistently resulted in liver metastases (increases in the number of tumor nodules in the liver), whereas inoculation of K1735M2 cells rarely did so. K1735M2L5 cells invaded the basement membrane Matrigel in greater numbers than did K1735M2 cells, suggesting that the metastatic potential of… (More)


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