Characterization of a lanosterol 14 alpha-demethylase from Pneumocystis carinii.

  title={Characterization of a lanosterol 14 alpha-demethylase from Pneumocystis carinii.},
  author={Ian J Morales and Pawan Kumar Vohra and Veenu Puri and Theodore J. Kottom and Andrew H. Limper and Charles Thomas},
  journal={American journal of respiratory cell and molecular biology},
  volume={29 2},
Pneumocystis carinii (PC) causes severe pneumonia in immunocompromised patients. PC is intrinsically resistant to treatment with azole antifungal medications. The enzyme lanosterol 14 alpha-demethylase (Erg11) is the target for azole antifungals. We cloned PCERG11 and compared its sequence to Erg11 proteins present in azole-resistant organisms, and performed chromosomal and Northern blot analysis for PCERG11. Of 13 potential sites which could confer resistance to azoles, two were identical to… CONTINUE READING

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