Characterization of a kidney proximal tubule cell line, LLC-PK1, expressing endocytotic active megalin.

@article{Nielsen1998CharacterizationOA,
  title={Characterization of a kidney proximal tubule cell line, LLC-PK1, expressing endocytotic active megalin.},
  author={Rikke Beck Nielsen and Henrik Birn and S\oren K Moestrup and Matt Nielsen and Pierre J. Verroust and Erik Ils\o Christensen},
  journal={Journal of the American Society of Nephrology : JASN},
  year={1998},
  volume={9 10},
  pages={1767-76}
}
Reabsorption and cellular handling of glomerular filtered vitamins, peptides, and hormones in the proximal tubule are essential, but thus far, poorly elucidated processes. The multiligand receptor megalin, initially described as a Heymann nephritis antigen and later identified as a member of the LDL receptor gene family, mediates reabsorption of several molecules, such as transcobalamin-vitamin B12 and albumin, in the proximal tubule. Consequently, a differentiated cell line of proximal tubular… CONTINUE READING