A review on biodegradable polymeric materials for bone tissue engineering applications
- MI Sabir, X Xu, L Li
- J Mater Sci,
This study evaluated a novel bone substitute composed of biodegradable polylactic acid (PLA) chips and hydroxyapatite (HA) powder. Using a microinjection molding technique, we manufactured tetrapod-shaped PLA chips, which are known to resist external loading. The roughness of the chip surface allowed for cell attachment. Also, no in vitro toxicity or reduced cellular proliferation was observed. The HA powder, made from porcine trabecular bones, had been characterized in previous studies. In the animal studies, pasted HA powder and PLA were implanted into the defective rabbit tibia. The control group was not treated with HA and PLA powder. Using X-ray analysis, micro-computed tomography, hematoxylin and eosin staining, and pathological examination for 12 weeks, we confirmed that the PLA/HA hybrid bone substitute has a potential of clinical application.