Characterization of a human small cell lung carcinoma cell line with acquired resistance to cis-diamminedichloroplatinum(II) in vitro.

Abstract

A 6.4-fold cis-diamminedichloroplatinum(II) (CDDP) resistant human small cell lung carcinoma cell line (GLC4-CDDP) was developed to study acquired CDDP resistance in vitro. Compared to the sensitive cell line (GLC4), the GLC4-CDDP showed an increase in doubling time and a decrease in cloning efficiency, cellular size, double minutes per cell, cellular… (More)

Topics

Cite this paper

@article{Hospers1988CharacterizationOA, title={Characterization of a human small cell lung carcinoma cell line with acquired resistance to cis-diamminedichloroplatinum(II) in vitro.}, author={Geke A. P. Hospers and Nanno H. Mulder and Bas de Jong and L. de Ley and Donald R. A. Uges and Anne Marie J. Fichtinger-Schepman and Rik J. Scheper and Elisabeth G. E. de Vries}, journal={Cancer research}, year={1988}, volume={48 23}, pages={6803-7} }