Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis

@article{Liu2004CharacterizationOA,
  title={Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis},
  author={Lingling Liu and Jianxuan Zhang and Jian-Li Yuan and Yongjun Dang and Chenyi Yang and Xiujuan Chen and Jianing Xu and Long Yu},
  journal={Molecular Biology Reports},
  year={2004},
  volume={32},
  pages={41-45}
}
AbstractProtein phosphatase 3 (PPP3, formerly PP2B, Calcineurin), a serine/ threonine protein phosphatase, is a heterodimer composed of one catalytic subunit (PPP3C, Calcineurin A) and one regulatory subunit (PPP3R, Calcineurin B). PPP3R, an EF-hand Ca2+ binding protein, contains four high-affinity EF-hand calcium-binding sites, indicating that PPP3 plays critical roles in many calcium-mediated signal transduction pathways. PPP3R has two isoforms, PPP3R1 (also known as PP2Bβ1) and PPP3R2 (also… 
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TLDR
It is shown that overexpression of the RCN2 gene, which encodes a negative regulator of calcineurin, is beneficial for vps13Δ cells and the molecular mechanism underlying this effect through site-directed mutagenesis of RCN1 and Rcn2 is studied.
Calcineurin tax-6 regulates male ray development and counteracts with kin-29 kinase in Caenorhabditis elegans
TLDR
It is suggested that balanced phosphorylation mediated by tax-6 and kin-29 is required for proper development of T lineage rays, and tax- 6 and sma-6 may function in a parallel pathway in the developmental process of V5 lineage ray 1.
Direct Evidence for Calcineurin Binding to the Exon-7 Loop of the Sodium-Bicarbonate Cotransporter NBCn1
TLDR
A new perspective on concurrent studies of NBCn1 in various tissues is provided by using cell-free binding assays to investigate the interaction ofNBCn1 with the calcineurin (Cn) isoform PPP3CA, and the protein domain Exon 7 binds Cn with an equilibrium dissociation constant of 30 +/- 15 nm.
Molecular analysis of CIB4 gene and protein in Kermani sheep
TLDR
Although it was demonstrated that CIB4 is a testis-specific gene, expressed only in the testis and it interacts with other proteins, the mechanisms by which C IB4 expression is regulated need to be elucidated.
Calcineurin Links Mitochondrial Elongation with Energy Metabolism.
Calcineurin inactivation inhibits pyruvate dehydrogenase complex activity and induces the Warburg effect
TLDR
It is shown that calcineurin interacts with pyruvate dehydrogenase complex (PDC), a mitochondrial gatekeeper enzyme that connects two key metabolic pathways of cells, glycolysis and the tricarboxylic acid cycle, and suggests that CNIs may promote tumorigenesis through inhibition of the calcineURin-PDC pathway.
Calcineurin is required for male sex pheromone biosynthesis and female acceptance
TLDR
It is demonstrated that HaCNA acts as downstream signal of PBAN/Ca2+ and plays an important role in PBAN‐induced male sex pheromone biosynthesis and female mating acceptance.
The effect of calcineurin inhibition on the expression and activation of renal electrolyte transporters
TLDR
A novel mechanism explaining CNI-induced hypercalciuria, driven by the activation of NCC, is proposed and the relationship between sodium and calcium handling in the DCT is discussed.
Transcriptomic analysis of Mandarin fish brain cells infected with infectious spleen and kidney necrosis virus with an emphasis on retinoic acid-inducible gene 1-like receptors and apoptosis pathways.
The Immunosuppressant Brasilicardin: Determination of the Biosynthetic Gene Cluster in the Heterologous Host Amycolatopsis japonicum.
TLDR
Investigation of the genes flanking the previously defined brasilicardin biosynthetic gene cluster revealed two novel genes (bra0, bra12), which are involved in brasilicARDin biosynthesis: bra12 encodes a transcriptional activator of the brasicardin gene cluster and bra0 codes for a dioxygenase involved in methoxylation of brasilicards.
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References

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TLDR
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TLDR
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