Characterization of a human fetal spinal cord stem cell line, NSI-566RSC, and its induction to functional motoneurons.

@article{Guo2010CharacterizationOA,
  title={Characterization of a human fetal spinal cord stem cell line, NSI-566RSC, and its induction to functional motoneurons.},
  author={Xiufang Guo and Karl K Johe and Peter Molnar and Hedvika Davis and James Hickman},
  journal={Journal of tissue engineering and regenerative medicine},
  year={2010},
  volume={4 3},
  pages={181-93}
}
Specific neuronal subtypes, especially motoneurons (MNs), derived from human stem cells provide a significant therapeutic potential for spinal cord diseases, such as amyotrophic lateral sclerosis (ALS) and spinal cord injury. So far, in vitro, MNs have only been successfully induced from embryonic stem cells (hESC) and human fetal cortical progenitors. Although neural progenitors from spinal cord would be a likely source for generating MNs, there has been no study reporting successful in vitro… CONTINUE READING
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