Characterization of a human cell line (NK-92) with phenotypical and functional characteristics of activated natural killer cells.

@article{Gong1994CharacterizationOA,
  title={Characterization of a human cell line (NK-92) with phenotypical and functional characteristics of activated natural killer cells.},
  author={J H Gong and Guitta Maki and Hans G. Klingemann},
  journal={Leukemia},
  year={1994},
  volume={8 4},
  pages={652-8}
}
The cell line described here was established for a 50-year-old male patient with rapidly progressive non-Hodgkin's lymphoma whose marrow was diffusely infiltrated with large granular lymphocytes (LGL). Immunophenotyping of marrow blasts and peripheral lymphocytes was positive for CD56, CD2 and CD7, and negative for CD3. Cytotoxicity of peripheral blood mononuclear cells at an effector: target (E:T) cell ratio of 50:1 was 79% against K562 cells and 48% against Daudi cells. To establish the line… CONTINUE READING
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