Characterization of a highly conserved histone related protein, Ydl156w, and its functional associations using quantitative proteomic analyses.

@article{Gilmore2012CharacterizationOA,
  title={Characterization of a highly conserved histone related protein, Ydl156w, and its functional associations using quantitative proteomic analyses.},
  author={Joshua M. Gilmore and Mihaela E. Sardiu and Swaminathan Venkatesh and Brent Stutzman and Allison Peak and Chris W. Seidel and Jerry L. Workman and Laurence Florens and Michael P Washburn},
  journal={Molecular & cellular proteomics : MCP},
  year={2012},
  volume={11 4},
  pages={M111.011544}
}
A significant challenge in biology is to functionally annotate novel and uncharacterized proteins. Several approaches are available for deducing the function of proteins in silico based upon sequence homology and physical or genetic interaction, yet this approach is limited to proteins with well-characterized domains, paralogs and/or orthologs in other species, as well as on the availability of suitable large-scale data sets. Here, we present a quantitative proteomics approach extending the… CONTINUE READING
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