Characterization of a glucocorticosteroid-induced inhibitor of interferon-gamma induction of HLA-DR expression.


Interferon gamma (IFN-gamma) induces human leukocyte antigen (HLA)-DR antigen expression on a variety of cell types, and in human skin cells this induction is inhibited by trypsin inhibitors. Recently a trypsin-like protease was characterized whose activity is required for HLA-DR induction in a hybrid epidermal cell line. Glucocorticosteroids also inhibit… (More)