Characterization of a fission yeast mutant which displays defects in cell wall integrity and cytokinesis.

@article{Ishiguro2001CharacterizationOA,
  title={Characterization of a fission yeast mutant which displays defects in cell wall integrity and cytokinesis.},
  author={Junpei Ishiguro and Sanae Shimada and Mbalaviele Gabriel and Marie Kopeck{\'a}},
  journal={Genes & genetic systems},
  year={2001},
  volume={76 4},
  pages={
          257-69
        }
}
The fission yeast cps6-153 mutant was originally isolated based on its hypersensitivity to the spindle poison isopropyl N-3-chlorophenyl carbamate (CIPC). The mutant also shows defects in both cell wall integrity and cytokinesis, resulting in the accumulation of unseparated cells with weakened cell walls. The arrested cells display a disoriented alignment of cytoplasmic microtubules. When the mutant cells are cultivated at high temperature (35 degrees C), both cell walls and septa become very… CONTINUE READING