Characterization of a filovirus (Měnglà virus) from Rousettus bats in China

@article{Yng2019CharacterizationOA,
  title={Characterization of a filovirus (Měngl{\`a} virus) from Rousettus bats in China},
  author={Xīngl{\'o}u Y{\'a}ng and Chee Wah Tan and Danielle E. Anderson and Rendi Jiang and Bei Li and Wei Zhang and Yan Zhu and Xiao Fang Lim and Peng Zhou and Xiang-Ling Liu and Wuxiang Guan and Libiao Zhang and Shi-Yue Li and Yunzhi Zhang and Lin‐Fa Wang and Zh{\`e}ngl{\`i} Sh{\'i}},
  journal={Nature Microbiology},
  year={2019},
  volume={4},
  pages={390-395}
}
Filoviruses, especially Ebola virus (EBOV) and Marburg virus (MARV), are notoriously pathogenic and capable of causing severe haemorrhagic fever diseases in humans with high lethality1,2. The risk of future outbreaks is exacerbated by the discovery of other bat-borne filoviruses of wide genetic diversity globally3–5. Here we report the characterization of a phylogenetically distinct bat filovirus, named Měnglà virus (MLAV). The coding-complete genome of MLAV shares 32–54% nucleotide sequence… 

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TLDR
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TLDR
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TLDR
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Comparative analyses of small molecule and antibody inhibition on glycoprotein‐mediated entry of Měnglà virus with other filoviruses

TLDR
The findings in the study confirmed that MLAV viral entry is biologically distinct but has similarities to MARV, and confirmed the possibility of developing these inhibitors as broad‐spectrum filovirus antivirals.

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TLDR
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TLDR
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