Characterization of a doxorubicin-resistant murine melanoma line: studies on cross-resistance and its circumvention.

@article{Supino1986CharacterizationOA,
  title={Characterization of a doxorubicin-resistant murine melanoma line: studies on cross-resistance and its circumvention.},
  author={Rosanna Supino and Ennio Prosperi and Franca Formelli and Mariangela Mariani and Giorgio Parmiani},
  journal={British Journal of Cancer},
  year={1986},
  volume={54},
  pages={33 - 42}
}
A B16 mouse melanoma cell line resistant to doxorubicin was obtained by continuous in vitro exposure to the drug. The ID50 for this line was 200 times higher than that for the parental cell line. The resistant cell line had some biological characteristics similar to those of the sensitive parental cell line, like saturation density and protein content. Differences were found in doubling time which was longer, cloning efficiency which was lower and DNA content which was higher in the resistant… CONTINUE READING

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