Characterization of a cytochrome P450 gene (CYP4G) and modulation under different exposures to xenobiotics (tributyltin, nonylphenol, bisphenol A) in Chironomus riparius aquatic larvae.

@article{MartnezPaz2012CharacterizationOA,
  title={Characterization of a cytochrome P450 gene (CYP4G) and modulation under different exposures to xenobiotics (tributyltin, nonylphenol, bisphenol A) in Chironomus riparius aquatic larvae.},
  author={Pedro Mart{\'i}nez-Paz and M{\'o}nica A. {\'A}lvarez Morales and Jos{\'e} Luis Mart{\'i}nez-Guitarte and Gonzalo Gonz{\'a}lez Morcillo},
  journal={Comparative biochemistry and physiology. Toxicology & pharmacology : CBP},
  year={2012},
  volume={155 2},
  pages={
          333-43
        }
}
Cytochrome P450 family members participate in xenobiotic transformation as a detoxification mechanism. We have characterized a CYP gene, assigned to the 4G family, in Chironomus riparius, a reference organism in aquatic toxicology. Due to the potential interest of CYP genes and P450 proteins for monitoring pollution effects at the molecular level, the alterations in the pattern of expression of this gene, induced by different xenobiotics, were analyzed. Different compounds, such as the biocide… CONTINUE READING
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