Characterization of a coronary vasoconstrictor produced by cultured endothelial cells.

@article{Hickey1985CharacterizationOA,
  title={Characterization of a coronary vasoconstrictor produced by cultured endothelial cells.},
  author={Kathleen T. Hickey and Gabor M. Rubanyi and R. J. Birch Paul and Robert F. Highsmith},
  journal={The American journal of physiology},
  year={1985},
  volume={248 5 Pt 1},
  pages={
          C550-6
        }
}
The vasoactive effects of media obtained from bovine aortic endothelial cells (EC) in culture were directly tested on isolated rings of the porcine left anterior descending coronary artery. Increasing concentrations of EC-conditioned culture media resulted in progressive dose-dependent increments in isometric tension in porcine, bovine, and canine coronary arteries; the response did not require an intact endothelium. Control (nonconditioned) media and that conditioned by fibroblasts or vascular… CONTINUE READING

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