Characterization of a component of the yeast secretion machinery: identification of the SEC18 gene product.

@article{Eakle1988CharacterizationOA,
  title={Characterization of a component of the yeast secretion machinery: identification of the SEC18 gene product.},
  author={Kurt Eakle and Mark Bernstein and Scott D Emr},
  journal={Molecular and cellular biology},
  year={1988},
  volume={8 10},
  pages={4098-109}
}
SEC18 gene function is required for secretory protein transport between the endoplasmic reticulum (ER) and the Golgi complex. We cloned the SEC18 gene by complementation of the sec18-1 mutation. Gene disruption has shown that SEC18 is essential for yeast cell growth. Sequence analysis of the gene revealed a 2,271-base-pair open reading frame which could code for a protein of 83.9 kilodaltons. The predicted protein sequence showed no significant similarity to other known protein sequences. In… CONTINUE READING

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