Characterization of a cholecystokinin 8-generating endoprotease purified from rat brain synaptosomes.

@article{Viereck1992CharacterizationOA,
  title={Characterization of a cholecystokinin 8-generating endoprotease purified from rat brain synaptosomes.},
  author={J C Viereck and Margery C. Beinfeld},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 27},
  pages={19475-81}
}
An endoproteolytic activity that specifically cleaves CCK 33, producing CCK 8, has been purified from a rat brain synaptosome preparation. The purification, which included anion exchange, chromatofocusing, hydroxyapatite, and gel filtration chromatography, resulted in a greater than 3000-fold increase in specific activity. This neutral endoprotease (pH… CONTINUE READING