Characterization of a candidate Borrelia burgdorferi beta3-chain integrin ligand identified using a phage display library.

@article{Coburn1999CharacterizationOA,
  title={Characterization of a candidate Borrelia burgdorferi beta3-chain integrin ligand identified using a phage display library.},
  author={Jenifer Coburn and Wairimu Chege and Loranne Magoun and Sarah C Bodary and John M Leong},
  journal={Molecular microbiology},
  year={1999},
  volume={34 5},
  pages={926-40}
}
The spirochaetal agents of Lyme disease, Borrelia burgdorferi (sensu lato) bind to integrins alphaIIbbeta3, alphavbeta3 and alpha5beta1 in purified form and on the surfaces of human cells. Using a phage display library of B. burgdorferi (sensu stricto) DNA, a candidate ligand for beta3-chain integrins was identified. The native B. burgdorferi protein, termed p66, is known to be recognized by human Lyme disease patient sera and to be expressed on the surface of the spirochaete. We show here that… CONTINUE READING

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