Characterization of a cancer cachectic factor

  title={Characterization of a cancer cachectic factor},
  author={Penio T. Todorov and Peter Cariuk and Andrew Green and Brian H. Coles and Kenneth C. H. Fearon and Michael John Dr. Tisdale},
CANCER cachexia is a syndrome of progressive wasting which has been suggested to be mediated by tumour-necrosis factor-α (ref. 1), interleukins 1 and 6 (ref. 2), interferon-γ (ref. 3) and leukaemia-inhibitory factor4. It has proved difficult to correlate levels of tumour-necrosis factor-α and interleukin-6 with cancer cachexia5,6, and the weight loss induced by leukaemia-inhibitory factor may be due to toxicity7. In the murine adenocarcinoma MAC 16, cachexia is mediated by circulatory catabolic… CONTINUE READING