Characterization of a cDNA encoding a protein with limited similarity to β1, 3-N-acetylglucosaminyltransferase


Glycosyltransferases constitute a large group of enzymes that are involved in a wide range of functions in all living organisms. By large–scale sequencing analysis of a human fetal brain cDNA library, we isolated a novel human putative glycosyltransferase gene named β3GnTL1. Its cDNA is 1372 base pair in length, encoding a predicted protein with 361 amino acid residues. The human β3GnTL1 is located to chromosome 17q25.3 by comparison of its cDNA with human gemome database. RT-PCR result shows the β3GnTL1 is expressed at various levels in most of tissues examined. Abbreviations:β3GnT –β1, 3-N-acetylglucosaminyltransferase;β4GalT –β1, 4-galactosyltransferase; GTs – glycosyltransferases.

DOI: 10.1023/B:MOLE.0000043552.32411.67

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@article{Zheng2004CharacterizationOA, title={Characterization of a cDNA encoding a protein with limited similarity to β1, 3-N-acetylglucosaminyltransferase}, author={Huarui Zheng and Yao Li and Chaoneng Ji and Jixi Li and Jiayi Zhang and Gang Yin and Jian Xu and Xin Ye and Maoqing Wu and Xianqiong Zou and Shaohua Gu and Yi Xie and Yu Mao}, journal={Molecular Biology Reports}, year={2004}, volume={31}, pages={171-175} }