Characterization of a bone morphogenetic protein-responsive Smad-binding element.

  title={Characterization of a bone morphogenetic protein-responsive Smad-binding element.},
  author={Kiyoshi Kusanagi and Hirofumi Inoue and Yasuhiro Ishidou and Hiromu K. Mishima and Masahiro Kawabata and Kohei Miyazono},
  journal={Molecular biology of the cell},
  volume={11 2},
Bone morphogenetic proteins (BMPs) are pleiotropic growth and differentiation factors belonging to the transforming growth factor-beta (TGF-beta) superfamily. Signals of the TGF-beta-like ligands are propagated to the nucleus through specific interaction of transmembrane serine/threonine kinase receptors and Smad proteins. GCCGnCGC has been suggested as a consensus binding sequence for Drosophila Mad regulated by a BMP-like ligand, Decapentaplegic. Smad1 is one of the mammalian Smads activated… CONTINUE READING
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