Characterization of a UL49-null mutant: VP22 of herpes simplex virus type 1 facilitates viral spread in cultured cells and the mouse cornea.

@article{Duffy2006CharacterizationOA,
  title={Characterization of a UL49-null mutant: VP22 of herpes simplex virus type 1 facilitates viral spread in cultured cells and the mouse cornea.},
  author={Carol Duffy and Jennifer H Lavail and Andrew N. Tauscher and Elizabeth G Wills and John A. Blaho and Joel D. Baines},
  journal={Journal of virology},
  year={2006},
  volume={80 17},
  pages={8664-75}
}
Herpes simplex virus type 1 (HSV-1) virions, like those of all herpesviruses, contain a proteinaceous layer termed the tegument that lies between the nucleocapsid and viral envelope. The HSV-1 tegument is composed of at least 20 different viral proteins of various stoichiometries. VP22, the product of the U(L)49 gene, is one of the most abundant tegument proteins and is conserved among the alphaherpesviruses. Although a number of interesting biological properties have been attributed to VP22… CONTINUE READING
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