Characterization of a Pseudomonas aeruginosa efflux pump contributing to aminoglycoside impermeability.

@article{WestbrockWadman1999CharacterizationOA,
  title={Characterization of a Pseudomonas aeruginosa efflux pump contributing to aminoglycoside impermeability.},
  author={S. Westbrock-Wadman and David R. Sherman and Michael J. Hickey and Silvija N. Coulter and Yong Qiang Zhu and Paul Warrener and Liem Nguyen and Ribhi Mohammad Shawar and Kim R. Folger and C Kendall Stover},
  journal={Antimicrobial agents and chemotherapy},
  year={1999},
  volume={43 12},
  pages={2975-83}
}
Pseudomonas aeruginosa can employ many distinct mechanisms of resistance to aminoglycoside antibiotics; however, in cystic fibrosis patients, more than 90% of aminoglycoside-resistant P. aeruginosa isolates are of the impermeability phenotype. The precise molecular mechanisms that produce aminoglycoside impermeability-type resistance are yet to be elucidated. A subtractive hybridization technique was used to reveal gene expression differences between PAO1 and isogenic, spontaneous… CONTINUE READING
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