Characterization of a Plasmodium falciparum erythrocyte-binding protein paralogous to EBA-175.

@article{Mayer2001CharacterizationOA,
  title={Characterization of a Plasmodium falciparum erythrocyte-binding protein paralogous to EBA-175.},
  author={D C Ghislaine Mayer and Osamu Kaneko and Diana E. Hudson-Taylor and Marion E. Reid and Louis H. Miller},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 9},
  pages={5222-7}
}
A member of a Plasmodium receptor family for erythrocyte invasion was identified on chromosome 13 from the Plasmodium falciparum genome sequence of the Sanger Centre (Cambridge, U.K.). The protein (named BAEBL) has homology to EBA-175, a P. falciparum receptor that binds specifically to sialic acid and the peptide backbone of glycophorin A on erythrocytes. Both EBA-175 and BAEBL localize to the micronemes, organelles at the invasive ends of the parasites that contain other members of the family… CONTINUE READING